1926 PHARMACOPOEIA IX CANNABIS ENTRY
THE PHARMACOPOEIA OF THE UNITED STATES OF AMERICA USP IX 1926 pages 98-99
Cannab.—Cannabis Indica, U.S.P. VIII Guaza Ganjah
The dried flowering tops of the pistillate plants of Cannabis sativa Linne, or of the variety indica Lamarck (Fam. Moracece), freed from the thicker stems and large foliage leaves and without the presence or admixture of more than 10 per cent. of fruits or other foreign matter. Cannabis, made into a fluidextract in which one hundred mils represent one hundred grammes of the drug, when assayed biologically, produces incoordination when administered to dogs in a dose of not more than 0.03 mil of fluidextract per kilogramme of body weight.
In dark green or greenish-brown and more or less agglutinated fragments, consisting of the short stems with their leaf-like bracts and pistillate flowers, some of the latter being replaced with more or less developed fruits; stems cylindrical, of varying length, not more than 3 mm. in diameter, longitudinally furrowed, light green to light brown, strigose-pubescent; leaves digitately com¬pound; leaflets, when soaked in water and spread out, linear-lanceolate, nearly sessile, margin deeply serrate; bracts ovate, pubescent, each enclosing one or two pistillate flowers, or more or less developed fruits; calyx dark green, pubes¬cent and somewhat folded around the ovary or fruit; styles two, filiform and pubescent; ovary with a single campylotropous ovule; fruit light green to light brown, broadly ellipsoidal, about 3.5 mm. in length, finely wrinkled and slightly reticulated; odor agreeably aromatic; taste characteristic.
The powder is dark green, giving a strong effervescence on the addition of dilute hydrochloric acid; numerous sharp pointed fragments of upper portion of non-glandular hairs and fragments of bracts and leaves showing yellowish-brown laticiferous vessels, rosette aggregates of calcium oxalate from 0.005 to 0.025 mm. in diameter; non-glaudular hairs unicellular, with a very slender pointed apex and a considerably enlarged base containing, usually in the lumen, some calcium carbonate; glandular hairs of two kinds, one with a short, one-celled stalk and the other with a multicellular, long, tongue-shaped stalk, the glandular portion being globular and consisting of from 8 to 16 cells, fragments of fruits with palisade-like, non-lignified sclerenchymatous cells, walls yellowish-brown, finely porous, the lumina usually containing air; tissues of embryo and endosperm with numerous oil globules and aleuronc grains, the latter from 0.005 to 0.01 mm. in diameter and consisting of large crystalloids and globoids.
The yield of alcohol extractive is not less than 8 per cent. and the alcoholic solution is of a bright green color.
Cannabis yields not more than 15 per cent. of ash.
Assay—Prepare a fluidextract and proceed as directed under Biological Assays (Part II).
Preparations—Extractum Cannabis Fluidextractum Cannabis Tinctura Cannabis.